EVALUATION OF PROGNOSIS IN PATIENTS WITH NON ST ELEVATION ACUTE CORONARY SYNDROMES WITH DIABETES MELLITUS OR METABOLIC Syndrome IN CORRELATION WITH INFLAMMATORY AND OXIDATIVE STRESS

Abstract

Aims: Evaluation of prognosis in patients with non ST elevation acute coronary syndromes (NSTE– ACS) and diabetes mellitus (DM) or metabolic syndrome (MS) in correlation with inflammatory and oxidative stress. Methods: 172 patients (pts) with NSTE-ACS were included in a prospective study for a period of 3 years and divided in three groups in relation with DM or MS association. Results: In NSTE-ACS patients with DM or MS it was observed a significant increased incidence of: lower than 40% ejection fraction (p<0.05); readmission for heart failure III-IV NYHA class and unstable angina (p<0.05); acute myocardial infarction and cardiac death (p<0.05) at 3 years of follow up in comparison with NSTE-ACS non MS non DM group. It was no significant differences between NSTE-ACS with diabetes mellitus and with metabolic syndrome groups at 3 years. In NSTE-ACS patients, presence of diabetes mellitus or metabolic syndrome were associated with significant higher incidence of inflammatory (p<0.05, p<0.01) and oxidative stress (p<0.05) at 6 months. Conclusions: In non ST elevation acute coronary syndromes patients, the presence of diabetes mellitus or metabolic syndrome was associated with significant higher incidence of low ejection fraction, readmission for heart failure III-IV NYHA class and unstable angina, acute myocardial infarction and cardiac death at 3 years of follow up and with significantly increased inflammatory and oxidative stress at 6 months.